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In addition to his professional and medical life Dr. Colby was interested in agriculture: he bred cattle, grew hops and wrote enthusiastically about the benefits a railway would bring to all community activities and interests.
Charles Carroll Colby writing about his father notes "His voluminous manuscripts - Under what
circumstances of physical suffering written - ill arranged, tautological, perhaps in some respects visionary, yet rich in the experience of years and in the reasonings and speculations of an acute reflective, never-resting mind".
According to his son's biographical notes. Dr. Colby was a devout and committed Christian - a Methodist - reading the Bible along with his medical readings, and like many of those times struggling with the broad issues of science and religion, mind and body. Moses Colby died 4 May 1863 after years of declining health.

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Lemira Strong Colby (1806-1889)
1885
Stanstead, Québec

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Mrs. Colby survived her husband by 26 years, living with her son Charles Carroll and his wife Harriet and her four grand children.
"Of my grandmother, I have a very distinct recollection as she lived till I was 21. Due to a fall she passed most of the time during her last years in a wheelchair and it is thus that I continue to picture her. To me she was very indulgent and I enjoyed reading aloud to her. One book which she enjoyed particularly was "Janet's Love and Service", written by Robertson, whose Scottish father had been the clergyman of Derby during the early years of grandmother's married life there. She felt great pride in her Stoddard ancestry and kept in touch with a widely ramified number of cousins. Viewing her character at this distance, I have
no doubt that it was greatly strengthened by her experiences as the wife of a country doctor in very active practice."
A Colby Family Sketch by Charles William Colby.